The Registration and Imaging of Brain Systems (RIBS) lab deals with brainfunction. The central motive is to elucidate the neuronal mechanisms underlying human brain function in health, in order to understand, diagnose and treat patients with mental disorders and with afflictions of the central and peripheral nervous system. We fully appreciate the fact that the use of todays’ techniques for measuring brainfunction generates questions about what we are actually measuring and how we should think about brain functions per se. We aim to understand the relationship between electrical, metabolic, cerebrovascular and neurochemical processes of neuronal populations on the one hand, and normal and abnormal behaviour on the other hand. To that end, we focus both on methodology and application in brain imaging research.