surgery_programsUtrecht Neuroprosthesis Project (UNP)

We will investigate feasibility of establishing communication in people with Locked-In Syndrome via a fully implantable Brain-Computer Interface system. The goal is to test the system in 3-5 people, and to enable them to click through menus in computer programs, by thinking of a particular hand movement, or by counting backwards. The research is conducted with support from Medtronic and is funded with a national grant from STW.



In iCONNECT we investigate feasibility of decoding sign language and inner speech from brain activity patterns. Goal is to develop an implantable Brain-Computer Interface system for people with Locked-In Syndrome with which they can control a speech computer for communication. The research is funded an ERC Advanced Grant awarded to Nick Ramsey.




The NeuroCIMT programme aims at developing novel ways of monitoring and treating neurological diseases and sensory impairments through quantitative models of the brain.  The goal of this project is to gain knowledge of the cortical organization of the human sensorimotor cortex, in order to further advance Brain-Computer Interface and Neuromodulation solutions for people with afflictions of the sensorimotor system.



In May 2015 a Proof of Concept grant from the ERC was awarded for initiating development of a fully implantable neuroprosthetic device for moinitoring brain function. In ‘NeMoFoil’ a protoptype implant will be designed and created, as well as a business and market plan. Aim is to attract commercial interest in further development and/or to optimize opportunities for obtaining further funding for development.




Functional MRI is increasingly included in planning for neurosurgical operations, mostly for removal of a tumor, or of the source of seizures in epilepsy. fMRI can provide locations of important brain areas that need to be spared. Due to complexity in acquiring and evaluating fMRI data, few hospitals have the capability to perform clinical fMRI. BrainCarta is a spin-off company from the UMC that will enable radiology departments to provide fMRI scans to neurologists and neurosurgeons even without specialists on site. Goal is to improve chances of tumor patients to early surgical removal, by increasing availability of fMRI in surgical decision making. The start up is funded in part with a Valorisation Phase 2 grant (equal to an SBIR grant) from STW.



USA Brain Initiative

Non-invasive imaging methods such as fMRI are indirect, measuring metabolic changes associated with brain activity, rather than the brain activity itself. To better understand how the human brain works, we need to better understand how indirect measurements relate to neuronal activity. In this project, we aim to improve our understanding by relating fMRI measurements directly to electrocorticography, optical and non-invasive electrical methods, at very high resolutions. Relationships between measures will be captured with mathematical models that link brain circuits to non-invasive imaging, and bridge carefully controlled activation paradigms between the human brain and animal models. With these models the quality of the non-invasive methods can be greatly enhanced, providing scientists with advanced tools to discover how our brain works.



 BNCI Horizon 2020

A consortium of 12 partners from academia, industry and healthcare have composed a Roadmap for development and application of  Brain-Computer Interface technology in the European arena. The roadmap will serve decision making in allocation of research funds of the EU in Horizon 2020. The project is funded by the EU, and is headed by Graz University. Please find more at: and you may find the roadmap here: BNCI roadmap



radertjes HCMIHCMI

Abnormal function of the fronto-striatal network is implicated in multiple psychiatric disorders. New methods to correct abnormal function are needed. As part of a large consortium we investigate whether real-time feedback of one node of the network (dorsolateral prefrontal cortex), enables people to regulate function of the whole network. Both Electrocorticography and 7 Tesla fMRI are employed. Funded by the Dutch Ministry of Education and Science, within the HCMI program. [2010-2015]