USA Brain Initiative

Non-invasive imaging methods such as fMRI are indirect, measuring metabolic changes associated with brain activity, rather than the brain activity itself. To better understand how the human brain works, we need to better understand how indirect measurements relate to neuronal activity. In this project, we aim to improve our understanding by relating fMRI measurements directly to electrocorticography, optical and non-invasive electrical methods, at very high resolutions. Relationships between measures will be captured with mathematical models that link brain circuits to non-invasive imaging, and bridge carefully controlled activation paradigms between the human brain and animal models. With these models the quality of the non-invasive methods can be greatly enhanced, providing scientists with advanced tools to discover how our brain works.