Principal Investigator

Mariska Vansteensel currently coordinates the research on implantable ECoG-based BCIs in the lab of Nick Ramsey and conducts research within the Utrecht NeuroProsthesis project, which aims to implement and validate implantable communication-BCIs for home use. In addition, she is the principal investigator of several projects related to Clinical implementation of BCIs and Pediatric Neuroscience.

Clinical Implementation of BCIs

Pediatric Neuroscience

PREP Project

Investigate whether EEG recordings could provide a rapid and easy approach to determine the quality of the neural signal changes prior to BCI implantation.

FLECK Project

Development of methods to maximize the quality of pediatric fMRI scans that pre-surgically map brain functions in young patients with refractory epilepsy.


Investigate language representation of children with language impairment and compare this with the activation patterns of healthy children.

Key Publications

1.     Vansteensel MJ, Jarosiewicz B (2020) Brain-computer interfaces for communication. Handb Clin Neurol 168: 67-85.

2.     Freudenburg ZV, Branco MP, Leinders S, van der Vijgh BH, Pels EGM, Denison T, van den Berg LH, Miller KJ, Aarnoutse EJ, Ramsey NF, Vansteensel MJ (2019) Sensorimotor ECoG Signal Features for BCI Control: A Comparison Between People With Locked-In Syndrome and Able-Bodied Controls. Front Neurosci 13: 1058.

3.     Pels EGM, Aarnoutse EJ, Leinders S, Freudenburg ZV, Branco MP, van der Vijgh BH, Snijders TJ, Denison T, Vansteensel MJ, Ramsey NF (2019) Stability of a chronic implanted brain-computer interface in late-stage amyotrophic lateral sclerosis. Clin Neurophysiol 130: 1798-1803.

4.     Pels EGM, Aarnoutse EJ, Ramsey NF, Vansteensel MJ (2017) Estimated prevalence of the target population for brain-computer interface neurotechnology in the Netherlands. Neurorehabil Neural Repair 31: 677-685.

5.     Bruurmijn MLCM, Pereboom IPL, Vansteensel MJ, Raemaekers MAH, Ramsey NF (2017) Preservation of hand movement representation in the sensorimotor areas of amputees. Brain 140: 3166-3178.

6.     Vansteensel MJ, Kristo G, Aarnoutse EJ, Ramsey NF (2017) The brain-computer interface researcher’s questionnaire: from research to application. Brain-Comput Interfaces 4: 236-247.

7.     Vansteensel MJ, Pels EG, Bleichner MG, Branco MP, Denison T, Freudenburg ZV, Gosselaar P, Leinders S, Ottens TH, Van Den Boom MA, Van Rijen PC, Aarnoutse EJ, Ramsey NF (2016) Fully implanted brain-computer interface in a locked-in patient with ALS. N Eng J Med 375: 2060-2066.

8.  Branco MP, Freudenburg ZV, Aarnoutse EJ, Bleichner MG, Vansteensel MJ, Ramsey NF (2016) Decoding hand gestures from primary somatosensory cortex using high-density ECoG. NeuroImage 147: 130-142.


10.  Ramsey NF, Aarnoutse EJ, Vansteensel MJ (2014) Brain implants for substituting lost motor function: state of the art and potential impact on lives of motor-impaired seniors. Gerontology 60: 366-72.


  • Lisette Charbonnier, Postdoc


  • Marc van Hulle, KU Leuven
  • Kees Braun, UMC Utrecht
  • Frank Wijnen, University of Utrecht
  • Iris Selten, Univerisity of Utrecht

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