Principal Investigator

Mariska Vansteensel currently coordinates the research on implantable ECoG-based BCIs in the lab of Nick Ramsey and conducts research within the Utrecht NeuroProsthesis project, which aims to implement and validate implantable communication-BCIs for home use. In addition, she is the principal investigator of several projects related to Clinical implementation of BCIs and Pediatric Neuroscience.

Clinical Implementation of BCIs

Pediatric Neuroscience

PREP Project

Investigate whether EEG recordings could provide a rapid and easy approach to determine the quality of the neural signal changes prior to BCI implantation.

FLECK Project

Development of methods to maximize the quality of pediatric fMRI scans that pre-surgically map brain functions in young patients with refractory epilepsy.


Investigate language representation of children with language impairment and compare this with the activation patterns of healthy children.

Key Publications

  1. Vansteensel MJ, Selten IS, Charbonnier L, Berezutskaya J, Raemaekers MAH, Ramsey NF, Wijnen F. Reduced brain activation during spoken language processing in children with developmental language disorder and children with 22q11.2 deletion syndrome. Neuropsychologia, in press.
  2. Charbonnier L, Raemaekers MAH, Cornelisse PA, Verwoert M, Braun KPJ, Ramsey NF, Vansteensel MJ. A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children. Front Pediatr. 2020 Nov 17;8:587593. 
  3. Leinders S, Vansteensel MJ, Branco MP, Freudenburg ZV, Pels EGM, Van der Vijgh B, Van Zandvoort MJE, Ramsey NF, Aarnoutse EJ. Dorsolateral prefrontal cortex-based control with an implanted brain-computer interface. Sci Rep. 2020 Sep 22;10(1):15448. 
  4. Freudenburg ZV, Branco MP, Leinders S, van der Vijgh BH, Pels EGM, Denison T, van den Berg LH, Miller KJ, Aarnoutse EJ, Ramsey NF, Vansteensel MJ. Sensorimotor ECoG Signal Features for BCI Control: A Comparison Between People With Locked-In Syndrome and Able-Bodied Controls. Front Neurosci. 2019 Oct 16;13:1058. 
  5. Branco MP, de Boer LM, Ramsey NF, Vansteensel MJ. Encoding of kinetic and kinematic movement parameters in the sensorimotor cortex: A Brain-Computer Interface perspective. Eur J Neurosci. 2019 Sep;50(5):2755-2772.
  6. Pels EGM, Aarnoutse EJ, Ramsey NF, Vansteensel MJ.Estimated Prevalence of the Target Population for Brain-Computer Interface Neurotechnology in the Netherlands. Neurorehabil Neural Repair. 2017 Jul;31(7):677-685.
  7. Vansteensel MJ, Pels EGM, Bleichner MG, Branco MP, Denison T, Freudenburg ZV, Gosselaar P, Leinders S, Ottens TH, Van Den Boom MA, Van Rijen PC, Aarnoutse EJ, Ramsey NF. Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS. N Engl J Med. 2016 Nov 24;375(21):2060-2066. 
  8. Vansteensel MJ, Bleichner MG, Freudenburg ZV, Hermes D, Aarnoutse EJ, Leijten FS, Ferrier CH, Jansma JM, Ramsey NF. Spatiotemporal characteristics of electrocortical brain activity during mental calculation. Hum Brain Mapp. 2014 Dec;35(12):5903-20. 
  9. Vansteensel MJ, Bleichner MG, Dintzner LT, Aarnoutse EJ, Leijten FS, Hermes D, Ramsey NF. Task-free electrocorticography frequency mapping of the motor cortex. Clin Neurophysiol. 2013 Jun;124(6):1169-74. 
  10. Bauer PR, Vansteensel MJ, Bleichner MG, Hermes D, Ferrier CH, Aarnoutse EJ, Ramsey NF. Mismatch between electrocortical stimulation and electrocorticography frequency mapping of language. Brain Stimul. 2013 Jul;6(4):524-31. 
  11. Vansteensel MJ, Hermes D, Aarnoutse EJ, Bleichner MG, Schalk G, van Rijen PC, Leijten FS, Ramsey NF.Brain-computer interfacing based on cognitive control. Ann Neurol. 2010 Jun;67(6):809-16. 
  12. Deboer T, Vansteensel MJ, Détári L, Meijer JH. Sleep states alter activity of suprachiasmatic nucleus neurons.Nat Neurosci. 2003 Oct;6(10):1086-90.


  • Lisette Charbonnier, Postdoc


  • Marc van Hulle, KU Leuven
  • Mansoureh Fahimi Hnazaee, KU Leuven
  • Kees Braun, UMC Utrecht
  • Frank Wijnen, University of Utrecht
  • Iris Selten, Univerisity of Utrecht
  • Nathan Crone, Johns Hopkins University